Taking NAD+ or NMN and Feeling Worse? You Might Be Missing This.
You did your research. You started taking NAD+, NMN, or NR because you wanted more energy, sharper focus, and to slow down the clock a little. Makes sense — the science is real.
But a few weeks in, something felt off. More tired than before. Mood swings you couldn't explain. Maybe even some hair thinning. You figured you'd push through, but the feeling didn't go away.
Here's what most supplement brands won't tell you: this isn't a coincidence.
The Hidden Cost of Boosting NAD+
When your body processes NAD+ — whether from direct supplementation or precursors like NMN and NR — it pulls from a shared resource called methyl groups.
Think of methyl groups as your body's behind-the-scenes maintenance crew. They're involved in hundreds of critical processes: regulating gene expression, producing neurotransmitters like serotonin and dopamine, detoxifying the liver, and keeping your cardiovascular system running clean.
The problem? NAD+ metabolism is a methyl group hog. The more NAD+ your body processes, the more methyl groups it burns through. If you're not actively replenishing them, you end up with what researchers call methyl depletion — and that's when things start going sideways.
Low energy despite supplementing. Mood instability. Brain fog that wasn't there before. Hair loss. These aren't signs that NAD+ isn't working. They're signs that your methylation balance is off.
The Fix Is Simpler Than You Think
The solution isn't to stop taking NAD+. It's to take it with something that keeps your methyl supply topped off.
That something is TMG (Trimethylglycine) — also called betaine. TMG is one of the most efficient methyl donors in human biochemistry. It donates methyl groups directly into the methylation cycle, replacing what NAD+ metabolism uses up and keeping your body's systems in balance.
When NAD+ and TMG work together, you get the cellular energy benefits of NAD+ without quietly draining the resources your body needs for everything else.
What to Actually Look for in a NAD+ Supplement
Most NAD+ products on the market are built around one thing: a high NAD+ dose. That's it. No consideration for what happens downstream in your metabolism.
A well-formulated NAD+ supplement should include TMG as a standard part of the formula — not as an afterthought, and not something you have to buy separately and remember to take.
inGreens Liposomal NAD+ 1800mg was built with this in mind. Each serving delivers 1200mg of high-activity NAD+ alongside 200mg of TMG — so your cells get the energy upgrade they need, and your methylation cycle stays protected.
Add liposomal delivery for superior absorption, and you've got a formula that's designed not just to work fast, but to work safely over time.
Because real anti-aging isn't just about pushing your biology harder. It's about keeping everything in balance while you do it.
This article is for informational and educational purposes only. It is not intended as medical advice. Please consult a qualified healthcare provider before starting any new supplement regimen.
